ModiQuest Research has developed an efficient mix of anti-collagen antibodies for the generation of a collagen antibody induced arthritis (CAIA) mouse animal model. ModiQuest Research offers these CAIA antibodies to clients. Please click here to go to our online shop directly.

Next to that under collaboration with third parties animal studies using these CAIA antibodies are offered by ModiQuest Research. For inquiries about full animal studies using the MQR-CAIA model please contact ModiQuest Research directly. Please click here for downloading a spec. sheet about the MQR-CAIA antibody model.

Collagen-induced arthritis is an antibody mediated disease.  Therefore, type II collagen specific antibodies can be used to induce arthritis in mice. Our mixture of type II collagen specific antibodies (2.6mg per animal) induces severe inflammation in the ankle and paws of DBA mice which resemble many aspects of arthritis. One of the biggest advantages of our monoclonal antibody-induced arthritis model is that severe arthritis is induced within 24-48 hours instead of the four weeks required to induce arthritis after immunization with type II collagen. ModiQuest Research recommends highly susceptible DBA/1 mice. Other strains may be used, however the amount of antibody cocktail required may vary. Thus, this model is ideal for rapidly screening therapeutics for the treatment of arthritis and to study the mechanisms involved in the development of arthritis.